Hi Bryan,
As Huib asked. Are you playing from the ME game? :chin:
There is a sound loop in the Talonsoft version that was taken care of in the new Matrix Edition.
Save the game and restart the game often is the answer. When I played the TS CS and had the endless sound loop I often turned down the sound.
To get rid of the repeating sound with the Talonsoft version, most of the time I just had to save and restart the file; sometimes I had to get all the way back to the desktop and restart EFII, and rarely I had to reboot the whole machine.