Sorry, I have never had a Vista installation myself.
I don't see why the game would not work though, lots of player's had it at the time - and maybe still do? Here's a few links I found on Vista here, hope they help:
http://www.matrixgames.com/forums/tm.asp...a�
https://www.theblitz.club/message_boards...ight=vista
https://www.theblitz.club/message_boards...ight=vista
I guess the bottom line is that is should work, and we'd just need to find out why it doesn't for you... Maybe just try to do a re-install.
Out of memory you should have it under C:\Matrix Games\John Tiller's Campaign Series, as the operating systems C\Program Files and C:\Program Files (x86) require special permissions, at least with W7 which was the version I finally upgraded into from XP.